SARS-CoV-2 protein NSP11

From Proteopedia

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 {{Theoretical_model}} {{Template:ModelConfidence}}
 To the right is an '''[[AlphaFold]]2''' 3D model of SARS CoV-2 Protein NSP11 (length = 13 amino acids, i.e. '''SADAQSFLNGFAV''' color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, ''i.e.'', model 5<ref name="MIT_ColabFold">[https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb MIT ColabFold]</ref>.
-[[Image:NSP11_AlphaFold2_Movie.gif|250px|left|thumb|'''Morph''' of the top 5 ranked [[AlphaFold]]2 models of '''SARS-CoV-2 Protein NSP6''', ''rainbow'' color coded N-C (blue to red)<ref name="MIT_ColabFold"/>.]]
+[[Image:NSP11_AlphaFold2_Movie.gif|250px|left|thumb|'''Morph''' of the top 5 ranked [[AlphaFold]]2 models of '''SARS-CoV-2 Protein NSP11''', ''rainbow'' color coded N-C (blue to red)<ref name="MIT_ColabFold"/>.]]
 == Function ==
 '''Non-structural protein 11 (NSP11)''' is the 13 amino acid peptide at the C-term of the large SARS-CoV-2 polyprotein ORF1ab (pp1a). It is the cleavage product of pp1a polyprotein by 3CLpro/Mpro protease at the nsp10/11 junction. Its function and whether it is actually expressed is not known.

Revision as of 15:18, 8 February 2022

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Caption for this structure

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Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

Model Confidence:

Very high (pLDDT > 90)

Confident (90 > pLDDT > 70)

Low (70 > pLDDT > 50)

Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions below 50 pLDDT may be unstructured in isolation.

To the right is an AlphaFold2 3D model of SARS CoV-2 Protein NSP11 (length = 13 amino acids, i.e. SADAQSFLNGFAV color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, i.e., model 5^[1].

Morph of the top 5 ranked AlphaFold2 models of SARS-CoV-2 Protein NSP11, rainbow color coded N-C (blue to red)^[1].

Function

Non-structural protein 11 (NSP11) is the 13 amino acid peptide at the C-term of the large SARS-CoV-2 polyprotein ORF1ab (pp1a). It is the cleavage product of pp1a polyprotein by 3CLpro/Mpro protease at the nsp10/11 junction. Its function and whether it is actually expressed is not known.