9y9y

Structural highlights

Function

DISA_MYCTU Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.[HAMAP-Rule:MF_01438] Also has diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. To a lesser extent, can also use ADP as substrate to produce c-di-AMP. Does not convert GTP to c-di-GMP. Also exhibits residual ATPase and ADPase activities in vitro.[HAMAP-Rule:MF_01438]^[1]

References

1. ↑ Bai Y, Yang J, Zhou X, Ding X, Eisele LE, Bai G. Mycobacterium tuberculosis Rv3586 (DacA) is a diadenylate cyclase that converts ATP or ADP into c-di-AMP. PLoS One. 2012;7(4):e35206. PMID:22529992 doi:10.1371/journal.pone.0035206