1hxy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1hxy.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1hxy.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1hxy| PDB=1hxy | SCENE= }}
{{STRUCTURE_1hxy| PDB=1hxy | SCENE= }}
-
'''CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II'''
+
===CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II===
-
==Overview==
+
<!--
-
The three-dimensional structure of a bacterial superantigen, Staphylococcus aureus enterotoxin H (SEH), bound to human major histocompatibility complex (MHC) class II (HLA-DR1) has been determined by X-ray crystallography to 2.6 A resolution (1HXY). The superantigen binds on top of HLA-DR1 in a completely different way from earlier co-crystallized superantigens from S.aureus. SEH interacts with high affinity through a zinc ion with the beta1 chain of HLA-DR1 and also with the peptide presented by HLA-DR1. The structure suggests that all superantigens interacting with MHC class II in a zinc-dependent manner present the superantigen in a common way. This suggests a new model for ternary complex formation with the T-cell receptor (TCR), in which a contact between the TCR and the MHC class II is unlikely.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11432818}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11432818 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11432818}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Walse, B.]]
[[Category: Walse, B.]]
[[Category: Complex]]
[[Category: Complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:20:49 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:06:19 2008''

Revision as of 07:06, 1 July 2008

Image:1hxy.png

Template:STRUCTURE 1hxy

CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II

Template:ABSTRACT PUBMED 11432818

About this Structure

1HXY is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence., Petersson K, Hakansson M, Nilsson H, Forsberg G, Svensson LA, Liljas A, Walse B, EMBO J. 2001 Jul 2;20(13):3306-12. PMID:11432818

Page seeded by OCA on Tue Jul 1 10:06:19 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1hxy"
Personal tools