| Structural highlights
4a7c is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | , ,
| | NonStd Res: | |
| Related: | 2bik, 2xix, 1ywv, 2bzj, 2c3i, 1yxu, 2j2i, 1yxt, 2bzh, 1yxs, 1xqz, 1yi3, 2xiz, 1yxv, 1xr1, 2xiy, 2bil, 1yhs, 1yxx, 1xws, 2xj1, 2bzk, 2xj0, 2xj2, 1yi4, 2bzi |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Publication Abstract from PubMed
PIM kinases have become targets of interest due to their association with biochemical mechanisms affecting survival, proliferation and cytokine production. 1,2,3-Triazolo[4,5-b]pyridines were identified as PIM inhibitors applying a scaffold hopping approach. Initial exploration around this scaffold and X-ray crystallographic data are hereby described.
Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors.,Pastor J, Oyarzabal J, Saluste G, Alvarez RM, Rivero V, Ramos F, Cendon E, Blanco-Aparicio C, Ajenjo N, Cebria A, Albarran MI, Cebrian D, Corrionero A, Fominaya J, Montoya G, Mazzorana M Bioorg Med Chem Lett. 2012 Feb 15;22(4):1591-7. Epub 2012 Jan 5. PMID:22266039[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Pastor J, Oyarzabal J, Saluste G, Alvarez RM, Rivero V, Ramos F, Cendon E, Blanco-Aparicio C, Ajenjo N, Cebria A, Albarran MI, Cebrian D, Corrionero A, Fominaya J, Montoya G, Mazzorana M. Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1591-7. Epub 2012 Jan 5. PMID:22266039 doi:10.1016/j.bmcl.2011.12.130
|
