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Contents 1 Isocitrate Lyase from Mycobacterium tuberculosis 1.1 Relevance 1.2 Wild Type Protein 1.3 3-Bromopyruvate 1.4 3-Nitopropionate 2 References

Isocitrate Lyase from Mycobacterium tuberculosis

Relevance

Mycobacterium tuberculosis is a respiratory infection that causes numerous fatalities throughout the world. It lives in organisms and feeds off of host cells, which indicate a variety of lipases exist within M. tuberculosis. Current drugs that are on the market now target a small number of bacterial processes like cell wall formation and chromosomal replication. Although several antibiotics exist, all of them target these same mechanisms of inhibition. These commonalities have led to the prevalence of different multi-drug resistant (MDR) tuberculosis strains. Due to the high level of resistance, finding a lasting treatment for MDR TB infections has become very problematic. Studies into new mechanisms of inhibition will be crucial to prevent widespread outbreaks.

Wild Type Protein

3-Bromopyruvate

3-Nitopropionate

spinqualitylabelsall models Isocitrate Lyase Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image This is a default text for your page Perry Rabin/Sandbox 1. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue. Contents 1 Structure 2 Function 3 Disease 4 Structural highlights Structure Figure Legend Function Disease Structural highlights This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

References