Purine nucleoside phosphorylase

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spinqualitylabelsall models Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry 1v2h) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Purine nucleoside phosphorylase (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine[1]. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down. Disease PNP deficiency results in severe combined immunodeficiency[2].

3D structures of purine nucleoside phosphorylase

Updated on 31-July-2016

References

1. ↑ Bzowska A, Kulikowska E, Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther. 2000 Dec;88(3):349-425. PMID:11337031
2. ↑ Markert ML. Purine nucleoside phosphorylase deficiency. Immunodefic Rev. 1991;3(1):45-81. PMID:1931007