This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils. Tdp-43.
Function
Tdp-43 or TAR DNA-binding protein 43 is a heterogeneous nuclear ribonucleoprotein which has crucial roles in gene expression and alternative splicing, stress response, neuronal functions such as neurite outgrowth and many other cellular processes[1].
Disease
Relevance
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein.
