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From Proteopedia
DNA Single Strand Binding Proteins
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Function
Interactions
During the DNA replication process SSB's interact with single strand DNA. The single strand DNA has a slightly negative charge due to a negative charge on one of the oxygens that make up the phosphodiester bond. Therefore, the SSB often has amino acids that have a positive charge, like lysine and arginine, on the surface of the DNA binding surface.
