MRGPRX2 is a GPCR that is located in the cellular membranes of mast cells. It shares the same structural features of all GPCR's which include a , along with a domain that consists of , beta, and gamma subunits.
Background
Ligands
Significance
Structure
Heterotrimeric G-Protein Structure
Novel Characteristics
Toggle Switch
Previously known Tryptophan residue that acts as the Toggle Switch in GPCR is switched to a .
Sodium Site
PIF/LLF Motif
LLF Motif on .
DRY/ ERC Motif
Disulfide Bonds
Disulfide bond connecting .
Further Information
Function
Before Activation
After Activation
Clinical Relevance
3D Structures
References