3gfe

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Image:3gfe.png

Template:STRUCTURE 3gfe

Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor

Template:ABSTRACT PUBMED 19574047

About this Structure

3GFE is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Wurz RP, Pettus LH, Xu S, Henkle B, Sherman L, Plant M, Miner K, McBride H, Wong LM, Saris CJ, Lee MR, Chmait S, Mohr C, Hsieh F, Tasker AS. Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4724-8. Epub 2009 Jun 17. PMID:19574047 doi:10.1016/j.bmcl.2009.06.058

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