2gzl

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Image:2gzl.gif

2gzl, resolution 2.50Å

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Structure of 2C-methyl-D-erythritol 2,4-clycodiphosphate synthase complexed with a CDP derived fluorescent inhibitor

About this Structure

2GZL is a Single protein structure of sequence from Escherichia coli with ZN, 2AA and GPP as ligands. This structure superseeds the now removed PDB entry 2AO4. Active as 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, with EC number 4.6.1.12 Full crystallographic information is available from OCA.

Reference

Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy., Crane CM, Kaiser J, Ramsden NL, Lauw S, Rohdich F, Eisenreich W, Hunter WN, Bacher A, Diederich F, Angew Chem Int Ed Engl. 2006 Feb 6;45(7):1069-74. PMID:16392111

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