4cau

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Template:STRUCTURE 4cau

Contents 1 THREE-DIMENSIONAL STRUCTURE OF DENGUE VIRUS SEROTYPE 1 COMPLEXED WITH 2 HMAB 14C10 FAB 2 Function 3 About this Structure 4 Reference

THREE-DIMENSIONAL STRUCTURE OF DENGUE VIRUS SEROTYPE 1 COMPLEXED WITH 2 HMAB 14C10 FAB

Template:ABSTRACT PUBMED 22723463

Function

[Q689G3_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774]

About this Structure

4cau is a 5 chain structure with sequence from Dengue virus 1 and Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Teoh EP, Kukkaro P, Teo EW, Lim AP, Tan TT, Yip A, Schul W, Aung M, Kostyuchenko VA, Leo YS, Chan SH, Smith KG, Chan AH, Zou G, Ooi EE, Kemeny DM, Tan GK, Ng JK, Ng ML, Alonso S, Fisher D, Shi PY, Hanson BJ, Lok SM, Macary PA. The structural basis for serotype-specific neutralization of dengue virus by a human antibody. Sci Transl Med. 2012 Jun 20;4(139):139ra83. PMID:22723463 doi:10.1126/scitranslmed.3003888