Monoamine oxidase

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spinqualitylabelsall models PDB ID 1gos Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
Human MAO-B dimer complex with FAD and phenyl-propenylidine derivative, 1gos
Ligands:	,
Activity:	Monoamine oxidase, with EC number 1.4.3.4
Related:	1h8r
Structural annotation: Resources: InterPro : Ipr001613, Ipr002937 Pfam : PF01593 SCOP : d1gosa1, d1gosa2, d1gosb2, d1gosb1 UniProt : P27338
Functional annotation: Cellular component: mitochondrial inner membrane membrane mitochondrion mitochondrial envelope integral to membrane Biological process: electron transport Molecular function: electron carrier activity amine oxidase activity oxidoreductase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Monoamine oxidase (MAO) are enzymes which catalyze the oxidation of monoamines. MAO contains FAD as co-factor. MAO-A and MAO-C are human enzymes which oxidize adrenaline, noradrenaline, serotonin and dopamine. MAO-B is a human enzyme which oxidizes benzylamine and phenylethylamine. For details on MAO-B see Monoamine oxidase b.

3D structures of monoamine oxidase

Update June 2012

MAO-A

2z5x, 2bxr, 2bxs – hMAO-A + inhibitor + FAD – human
2z5y - hMAO-A (mutant) + inhibitor + FAD
1o5w - MAO-A + inhibitor + FAD – rat

MAO-B

1gos – hMAO-B
3po7, 2xcg, 2xfn, 2xfp, 2xfq, 2xfu, 2vz2, 2vrl, 2vrm, 2v5z, 2v60, 2v61, 2c64, 2c65, 2c66, 2c67, 2byb, 2bk3, 1s2q, 1s2y, 1s3b, 1s3e, 1oj9, 1oja, 1ojc, 1ojd, 4a79, 4a7a – hMAO-B + inhibitor + FAD
2xfo, 2bk4, 2bk5 - hMAO-B (mutant) + inhibitor + FAD
2c72, 2c73, 2c75, 2c76 - hMAO-B (mutant) + FAD
2c70 - hMAO-B + FAD
3zyx - hMAO-B + methylene blue + FAD

MAO-C

3qj4 – hMAO-C + FAD

MAO-N

2vvl, 2vvm – MAO-N (mutant) + FAD – Aspergillus niger