O-GlcNAc transferase
From Proteopedia
O-GlcNac transferase (OGT) catalyzes the addition of N-acetylglucosamine (GlcNAc) to serine or threonine residues by O-glycosylation. OGT contains 2 subunits: a 110 kDa and a 78kDa. The 110 kDa subunit contains a superhelical domain with 13 tetratricopeptide (TPR) repeats. The TPR motif consists of 34 amino acids and mediates protein-protein interactions. For details see Human O-GlcNAc transferase.
3D structures of O-GlcNAc transferase
Updated on 01-April-2014
1fo8, 1fo9, 1foa - rOGT catalytic domain – rabbit
1w3b – hOGT TPR domain – human
2gak – mOGT – mouse
2j0a, 3otk – mOGT catalytic domain (mutant)
OGT binary complexes
2am3, 2am4 - rOGT catalytic domain + UDP-glucose derivative
2am5 - rOGT catalytic domain + UDP
2j0b - mOGT catalytic domain (mutant) + UDP
2apc - rOGT catalytic domain + UDP-GlcNAc phosphonate
2gam - mOGT + b-D-galactose + N-acetyl-galactosamine
3pe3, 3pe4 – hOGT TPR and catalytic domains+ peptide substrate
2jlb – XcOGT + UDP-GlcNAc phosphonate analog – Xanthomonas campestris
2xgm – XcOGT + alloxan + mesoxalylurea
2xgc - XcOGT + UDP-GlcNAc
2xgs - XcOGT + UDP
1nlm – OGT + UDP-acetylglucosamine – Escherichia coli
3ee5 – hOGT + UDP + NAG + galactose + naphthalene derivative
4ay5, 4gyw, 4gyy, 4gz3 - hOGT TPR and catalytic domains + UDP + NAG + glycopeptide
4cdr - hOGT TPR and catalytic domains + UDP-peptide conjugate
4gz5, 4gz6 - hOGT TPR and catalytic domains + UDP-GlcNAc
4n39, 4n3a, 4n3b, 4n3c - hOGT TPR and catalytic domains + UDP + host cell factor peptide
