Shikimate dehydrogenase
From Proteopedia
Shikimate dehydrogenase (AroE) catalyzes the conversion of shikimate and NADP+ to 3-dihydroshikimate, NADPH and H+. It is part of the shikimate pathway which is responsible for the biosynthesis of phenylalanine, tyrosine and tryptophan. This pathway is found in bacteria, fungi, plants, algae and parasites and is missing in animals and humans.
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3D Structures of shikimate dehydrogenase
Updated on 20-November-2014
AroE
1p74, 1p77 – AroE – Haemophilus influenzae
1wxd – TtAroE – Thermus thermophilus
2hk7, 2hk8 – AaAroE – Aquifex aeolicus
2egg – AroE – Geobacillus kaustophilus
3fbt – AroE/chorismate mutase – Clostridium acetobutylicum
3don – SeAroE – Staphylococcus epidermidis
3o8q – VcAroE – Vibrio cholerae
3pwz – AroE 3 – Pseudomonas putida
3phg – HpAroE – Helicobacter pylori
4foo, 4fpx – HpAroE (mutant)
3u62 – AroE – Thermotoga maritima
2nlo – CgAroE – Corynebacterium glutamicum
AroE complex with NADP
1nyt, 1vi2 – EcAroE + NADP – Escherichia coli
1nvt – MjAroE + NADP – Methanocaldococcus jannaschii
2cy0 – TtAroE + NADP
3toz – LmAroE + NAD – Listeria monocytogenes
3t4e – AroE + NAD – Salmonella enterica
3jyo - CgAroE + NAD
AroE complex with shikimate
2d5c – TtAroE + shikimate
3doo – SeAroE + shikimate
3pgj – VcAroE + shikimate
3phh – HpAroE + shikimate
4fos, 4fq8, 4fr5, 4fsh – HpAroE (mutant) + shikimate
3phj – HpAroE + 3-dihydroshikimate
AroE complex with NADP and shikimate
2ev9 – TtAroE + shikimate + NADP
2hk9 – AaAroE + shikimate + NADP
3sef – VcAroE + shikimate + NADP
3tnl – LmAroE + shikimate + NAD
3phi – HpAroE + shikimate + NADP
3jyp - CgAroE + quinate + NAD
3jyq - CgAroE + shikimate + NAD
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Michal Harel, Alexander Berchansky, Joel L. Sussman, Sohail Jooma
