4fia

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Template:STRUCTURE 4fia

Contents

Crystal Structure of Human CYP46A1 P450 with bicalutamide Bound

Template:ABSTRACT PUBMED 23288837

Function

[CP46A_HUMAN] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.

About this Structure

4fia is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Mast N, Zheng W, Stout CD, Pikuleva IA. Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response. J Biol Chem. 2013 Feb 15;288(7):4613-24. doi: 10.1074/jbc.M112.438754. Epub 2013 , Jan 3. PMID:23288837 doi:10.1074/jbc.M112.438754

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