3hj3

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Template:STRUCTURE 3hj3

Contents 1 Crystal Structure of the ChTS-DHFR F207A Non-Active Site Mutant 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal Structure of the ChTS-DHFR F207A Non-Active Site Mutant

Template:ABSTRACT PUBMED 24324854

Function

[Q5CGA3_CRYHO] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]

About this Structure

3hj3 is a 4 chain structure with sequence from Cryho. Full crystallographic information is available from OCA.

See Also

• Thymidylate synthase

Reference

• Martucci WE, Rodriguez JM, Vargo MA, Marr M, Hamilton AD, Anderson KS. Exploring novel strategies for AIDS protozoal pathogens: alpha-helix mimetics targeting a key allosteric protein-protein interaction in TS-DHFR. Medchemcomm. 2013 Sep;4(9). doi: 10.1039/C3MD00141E. PMID:24324854 doi:http://dx.doi.org/10.1039/C3MD00141E