Kinesin

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Template:STRUCTURE 2zfi

Function

Kinesins are eukaryotic motor proteins which move along microtubules^[1]. Kinesin (KIF) is a dimer consisting of 2 heavy chains and two light chains. The heavy chain contains the globular motor domain (MD), flexible neck linker (FNL) and a long coiled-coil stalk which intertwines to form the dimer. The light chain (KLC) forms the tail region. The KLC contains a cargo binding domain which is called TPR (Tetratricopeptide repeat). The KIFs are named by their gene number. KIF contains a forkhead-associated domain (FHA) which is involved in phosphopeptide recognition.

• Kar3 is kinesin protein in yeast.
  
• Eg5 or KIF11 is a kinesin (See Kinesin-5) which participates in mitosis.
  
• KCBP is a Kinesin-like Calmodulin Binding Protein.
  
• NOD is a Drosophila chromosome-associated kinesin.

See also CAP-Gly domain.

3D Structures of Kinesin

Updated on 07-April-2016

References

1. ↑ Hirokawa N, Noda Y, Tanaka Y, Niwa S. Kinesin superfamily motor proteins and intracellular transport. Nat Rev Mol Cell Biol. 2009 Oct;10(10):682-96. doi: 10.1038/nrm2774. PMID:19773780 doi:http://dx.doi.org/10.1038/nrm2774