Mitogen-activated protein kinase
From Proteopedia
Mitogen-activated protein kinase (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, MAP2K and MAP3K which are activated by phosphorylation.
- MAPK1 and MAPK3 are activated in response to growth factors.
- For MAPK2 representations see Michael Roberts/BIOL115/ERK2.
- MAPK6 is activated by phorbol esters.
- MAPK7 is activated by stress stimuli.
- MAPK8 (called also c-Jun N-terminal kinase 1 or JNK1), MAPK9, MAPK10 (called also c-Jun N-terminal kinase 3 or JNK3), MAPK11, MAPK12, MAPK13, MAPK14 are stress-activated.
- MAPK11 (also called p38-β MAPK), MAPK12 (also called p38-γ MAPK), MAPK13 (also called p38-δ MAPK), MAPK14 (also called p38-α MAPK) belong to the class called p38 MAPK.
3D Structures of Mitogen-activated protein kinase
Updated on 11-August-2015
