Function
Rho GTPase of higher vertebrates include RhoA, RhoB and RhoC. These 3 proteins share 85% sequence identity. RhoA is the more extensively studied among these three. RhoA regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. A number of proteins have been identified as targets of RhoA[1].
Disease
Mutations in RhoA were identified in diffuse gastric cancer[2].
Relevance
RhoA is thought to be important in mediating vasoconstriction in the penis[3].
Structural highlights
