Acetylcholine Binding Protein modulates synaptic transmission of acetylcholine in snails. The humanized version consists of a complex with Lobeline.
Function
Lobeline by itself can either activate or inhibit nicotinic acetylcholine receptors in the both CNS and PNS. Acetylcholine Binding Protein, on the other hand, binds acetylcholine, modulating its transmission through ligand-gated ion channels. Combined with Lobeline, this can cause a significant decrease in the activity of acetylcholine receptors by inhibiting receptor activity while also modulating transmission through such receptors.
Disease
The protein is associated with Alzheimer's Disease and Schizophrenia. Lobeline by itself is sold as a smoking aid due to its activity blocking the uptake of nicotine and its subsequent binding to nicotinic acetylcholine receptors.
Relevance
Structural highlights
The protein consists of and Acetylcholine Binding Protein.
