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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Function of your protein
The function of is dephosphorylating inositol, used in inositol signaling. The substrate of the enzyme is IP3 and the product is IP2,
Biological relevance and broader implications
The protein 7KIR is a protype member of a family of enzymes involved in dephosphorylation IP3. The two metal ions, Magnesium and Lithium, are particularly important in activation and inhibition of inositol signaling. Since these enzymes are seen in many different organisms, with slight mutations in the motif of the enzyme without change in function, understanding the mechanics of enzyme inhibition in this metabolic pathway would allow a better understanding of metabolic pathways.
Important amino acids
In the protein seen in the paper there is a mutation at residue 54, causing an . The catalytic amino acids are .
Structural highlights
This protein is a mutation of 1INP, it has thirteen structural elements. The amino acids in the bind to the substrate all participate in hydrogen bonding to the substrate and ligand. The structure is , the betta sheets allow for twisting of the molecule so that the ligand better fits within the enzyme. The helices allow for hydrogen bonding throughout to stabilize the structure with assistance from metal ions; specifically magnesium ions. [3]
Other important features
The ligand of the protein is known as , with a PDB ID of 2IP. The cyclic structure of the ligand could possibly assist with binding the substrate, the hydrogen bonding with various amino acids allows for many interactions with the enzyme.
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