transmembrane domain</scene> (red) spans the phospholipid bilayer of cellular membranes and attaches to the G-protein. The G-protein consists of 3 different domains: alpha (blue), beta (magenta), and gamma (yellow).' scene ='90/904305/Structure_overview/1'>

is a transmembrane protein.

Background

Ligands

Significance

Structure

Heterotrimeric G-Protein Structure

Novel Characteristics

Toggle Switch

Previously known Tryptophan residue that acts as the Toggle Switch in GPCR is switched to a .

Sodium Site

PIF/LLF Motif

LLF Motif on .

DRY/ ERC Motif

Disulfide Bonds

Disulfide bond connecting .

Further Information

Function

Before Activation

After Activation

Clinical Relevance

3D Structures

References