User:Karl Oberholser/Sandbox2
From Proteopedia
Histones HMfA and HMfB from Methanothermus fervidus
"The hyperthermophilic archaeon Methanothermus fervidus contains two small basic proteins, HMfA (68 amino acid residues) and HMfB (69 residues)that share a common ancestry with the eukaryal nucleosome core histones H2A, H2B, H3, and H4. HMfA and HMfB have sequences that differ at 11 locations, they have different structural stabilities, and the complexes that they form with DNA have different electrophoretic mobilities." [1]
Comparison of Structures
HMfA Seq: MGELPIAPIG RIIKNAGAER VSDDARIALA KVLEEMGEEI ASEAVKLAKH AGRKTIKAED IELARKMFK
HMfB Seq: MELPIAPIGR IIKDAGAERV SDDARITLAK ILEEMGRDIA SEAIKLARHA GRKTIKAEDI ELAVRRFKK
Template:STRUCTURE 1hta Template:STRUCTURE 1a7w
Template:STRUCTURE 1b67 The orthorombic form of PDB:1B67 is shown in the default scene as a dimer structure
Notes and References
- ↑ From abstract of K. Decanniere, A. M. Babu, K. Sandman, J. N. Reeve, U. Heinemann Crystal Structure of Recombinant Histones HMfA and HMfB from the Hyperthermophilic Methanothermus fervidus. J. Mol. Biol., 303, 35-47, 2000
