Aldose Reductase
From Proteopedia
Aldose Reductase (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway. The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR. The images at the left and at the right correspond to one representative AldR, i.e. the crystal structure of barley apo-Aldose Reductase (2bgq).
3D Structures of Aldose Reductase
Aldose Reductase
1abn, 1ads - hAldR +NADP – human 1xgd – hAldR (mutant) 3q67 – hAldR (mutant)+NADP 3afm – SsAldR A1-R – Sphingomonas sp. 3afn - SsAldR A1-R+NADP 1dla – pAldR - pig 1ah4 - pAldR+NADP 3krb – AldR+NADP – Ghiardia lamblia 2bgq – bAldR - barley 2bgs - bAldR+NADP
Aldose Reductase+inhibitors
3ghr, 3ghs, 3ght, 3ghu, 2r24, 2pzn, 3g5e, 2qxw, 2iki, 2i16, 2i17, 1t40, 1t41, 1us0, iel3 - hAldR +NADP+IDD inhibitors 3bcj, 1x97, 1x98, 1pwm, 1ef3 - hAldR+NADP+fidarestat 2pd5, 2dux, 2duz, 2dv0, 2fz8, 2fz9, 2hv5, 2hvn, 2hvo, 1mar - hAldR+NADP+zopolrestat 2fzb, 2fzd - hAldR+NADP+tolrestat 1z3n - hAldR+NADP+lidorestat 1pwl - hAldR+NADP+minalrestat 1iei - hAldR+NADP+zenarestat 1z89, 1z8a - hAldR+NADP+sulfonyl-pyridazinone 2pdg, 2pdh - hAldR+NADP+uracil inhibitor 2j8t, 1x96, 2acs, 2acu - hAldR+NADP+citrate 2acq - hAldR +NADP+glucose phosphate 2acr - hAldR +NADP+cacodylate 2ikg, 2ikh, 2ikj - hAldR+NADP+nitro-substituted inhibitor 2nvc, 2nvd - hAldR+NADP+isothiazole inhibitor 2pev, 2pf8, 2pfh - hAldR+NADP+IDD inhibitor+ fidarestat 2ipw, 2iq0, 2iqd, 2isf, 2ine, 2inz, 2is7 - hAldR+NADP+ acid 2f2k - hAldR+NADP+DEG 2pdn, 2pdq – hAldR (mutant)+NADP+uracil inhibitor 2pdb, 2pdf, 2pdi, 2pdm, 2pdx – hAldR (mutant)+NADP+zopolrestat 2pd9, 2pdw, 2pdy, 2agt – hAldR (mutant)+NADP+fidarestat 2pdk - hAldR (mutant)+NADP+sorbinil 2pdl - hAldR (mutant)+NADP+tolrestat 1az1 – hAldR (mutant)+NADP+alrestatin 1az2 - hAldR (mutant)+NADP+citrate 3lbo, 3ld5, 3lq, 3lz5l, 2pdc, 3lep, 3lqg, 3lz3, 3m4h, 2pdj, 2pdp, 2pdu - hAldR (mutant)+IDD inhibitors 3dn5 – hAldR+NADP+biaryl inhibitor 3fx4 – pAldR+NAP+thiazolidine derivative 3h4g – pAldR+NADP+fidarestat 1ah3 - pAldR+NADP+tolrestat 1ah0 - pAldR+NADP+sorbinil 1eko - pAldR+NADP+IDD inhibitor 2vdg – bAldR+NADP+butanol
