Aldose Reductase
From Proteopedia
Aldose Reductase (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway. The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR. The images at the left and at the right correspond to one representative AldR, i.e. the crystal structure of barley apo-Aldose Reductase (2bgq).
3D Structures of Aldose Reductase
Update May 2012
Aldose Reductase
1abn, 1ads, 3q65 - hAldR +NADP – human
1xgd – hAldR (mutant)
3q67 – hAldR (mutant)+NADP
3afm – SsAldR A1-R – Sphingomonas sp.
3afn - SsAldR A1-R+NADP
1dla – pAldR - pig
1ah4 - pAldR+NADP
3krb – AldR+NADP – Ghiardia lamblia
2bgq – bAldR - barley
2bgs - bAldR+NADP
Aldose Reductase+inhibitors
3ghr, 3ghs, 3ght, 3ghu, 2r24, 2pzn, 3g5e, 2qxw, 2iki, 2i16, 2i17, 1t40, 1t41, 1us0, 1el3, 3t42 - hAldR +NADP+IDD inhibitors
3onb, 3onc – hAldR (mutant) +NADP+IDD inhibitor
3u2c - hAldR +NADP+ NSAID inhibitor
3bcj, 1x97, 1x98, 1pwm, 1ef3 - hAldR+NADP+fidarestat
2pd5, 2dux, 2duz, 2dv0, 2fz8, 2fz9, 2hv5, 2hvn, 2hvo, 1mar - hAldR+NADP+zopolrestat
2fzb, 2fzd - hAldR+NADP+tolrestat
1z3n - hAldR+NADP+lidorestat
1pwl - hAldR+NADP+minalrestat
1iei - hAldR+NADP+zenarestat
1z89, 1z8a - hAldR+NADP+sulfonyl-pyridazinone
2pdg, 2pdh - hAldR+NADP+uracil inhibitor
2j8t, 1x96, 2acs, 2acu - hAldR+NADP+citrate
2acq - hAldR +NADP+glucose phosphate
2acr - hAldR +NADP+cacodylate
2ikg, 2ikh, 2ikj - hAldR+NADP+nitro-substituted inhibitor
2nvc, 2nvd - hAldR+NADP+isothiazole inhibitor
3p2v - hAldR+NADP+ benzothiazepine inhibitor
2pev, 2pf8, 2pfh - hAldR+NADP+IDD inhibitor+ fidarestat
2ipw, 2iq0, 2iqd, 2isf, 2ine, 2inz, 2is7 - hAldR+NADP+ acid
2f2k - hAldR+NADP+DEG
2pdn, 2pdq – hAldR (mutant)+NADP+uracil inhibitor
2pdb, 2pdf, 2pdi, 2pdm, 2pdx, 3len, 3m0i, 3mb9 – hAldR (mutant)+NADP+zopolrestat
2pd9, 2pdw, 2pdy, 2agt – hAldR (mutant)+NADP+fidarestat
2pdk - hAldR (mutant)+NADP+sorbinil
2pdl - hAldR (mutant)+NADP+tolrestat
1az1 – hAldR (mutant)+NADP+alrestatin
1az2 - hAldR (mutant)+NADP+citrate
3lbo, 3ld5, 3lql, 3lz5, 2pdc, 3lep, 3lqg, 3lz3, 3m4h, 2pdj, 2pdp, 2pdu, 3m64, 3mc5 - hAldR (mutant)+IDD inhibitors
3dn5 – hAldR+NADP+biaryl inhibitor
3rx2, 3rx3, 3rx4, 3s3g - hAldR+NADP+ sulindac inhibitor
3fx4 – pAldR+NADP+thiazolidine derivative
3h4g – pAldR+NADP+fidarestat
1ah3 - pAldR+NADP+tolrestat
1ah0 - pAldR+NADP+sorbinil
1eko - pAldR+NADP+IDD inhibitor
2vdg – bAldR+NADP+butanol
