1oia

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Image:1oia.gif

1oia, resolution 2.40Å

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U1A RNP DOMAIN 1-95

Overview

The crystal structure of the RNA binding domain of the U1 small nuclear ribonucleoprotein A, which forms part of the ribonucleoprotein complex involved in the excision of introns, has been solved. It contains a four-stranded beta sheet and two alpha helices. The highly conserved segments designated RNP1 and RNP2 lie side by side on the middle two beta strands. U1 RNA binding studies of mutant proteins suggest that the RNA binds to the four-stranded beta sheet and to the flexible loops on one end.

About this Structure

1OIA is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1NRC. Full crystallographic information is available from OCA.

Reference

Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A., Nagai K, Oubridge C, Jessen TH, Li J, Evans PR, Nature. 1990 Dec 6;348(6301):515-20. PMID:2147232

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