3vws

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Template:STRUCTURE 3vws

Contents

Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-107

Template:ABSTRACT PUBMED 23408636

Function

[Q6DLV0_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774]

About this Structure

3vws is a 1 chain structure with sequence from Dengue virus 3. Full crystallographic information is available from OCA.

Reference

  • Noble CG, Lim SP, Chen YL, Liew CW, Yap L, Lescar J, Shi PY. Conformational flexibility of the dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor. J Virol. 2013 Feb 13. PMID:23408636 doi:10.1128/JVI.00045-13

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