Background
Metabolic Role
Component of Endocannabinoid System
Structure
Catalytic triad
MGL has a classic catalytic triad that contains Ser-His-Asp. This triad has a natural attraction to Endocannabinoids, specifically 2-arachidonylglycerol (2-AG). 2-AG contributes to brain signals (neurons) to suppress the pain pathways when a patient is feeling depressed or suffering from any type of pain.
Catalytic Triad of MGL structure
Binding
Inhibition
Ligand Binding Site
Ligand within the Overall Structure of MGL
Overall Reaction
Literature
Additional Resources
Serine hydrolases
References
External links
