2b4g

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Template:STRUCTURE 2b4g

Contents

dihydroorotate dehydrogenase

Template:ABSTRACT PUBMED 18312275

Function

[Q57U83_9TRYP] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.

About this Structure

2b4g is a 4 chain structure with sequence from Trypanosoma brucei. Full crystallographic information is available from OCA.

See Also

Reference

  • Arakaki TL, Buckner FS, Gillespie JR, Malmquist NA, Phillips MA, Kalyuzhniy O, Luft JR, Detitta GT, Verlinde CL, Van Voorhis WC, Hol WG, Merritt EA. Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies. Mol Microbiol. 2008 Apr;68(1):37-50. Epub 2008 Feb 26. PMID:18312275 doi:10.1111/j.1365-2958.2008.06131.x

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