Tyrosine phosphatase
From Proteopedia
Tyrosine phosphatase (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways. PTPs are divided to 4 subfamilies. PTP class I contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. PTP class III contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP. For details on Yersinia PTP see Yersinia YopH.
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3D Structures of tyrosine phosphatase
Updated on 21-August-2014
Class I
Non-receptor type PTP
1a5y, 2hnp, 2hnq, 1oem, 1oeo, 1oes, 1oet, 1oeu, 1oev, 1sug, 2cm2, 2cm3, 3eu0, 3i80, 3a5j, 1bzc - hPTP-b catalytic domain – human
1gfy, 1i57, 1pa1, 2f6f, 3a5k, 3zv2, 3qkp, 3qkq - hPTP-b catalytic domain (mutant)
1wch – hPTP-e
3pdz - hPTP-e PDZ2 domain – NMR
1gm1 - mPTP-BL PDZ2 domain – mouse – NMR
1ozi - mPTP-BL PDZ2 domain (mutant) – NMR
3rgo – mPTP-1
2yz1 – mPTP SHPS-1 catalytic domain
1gwz, 2b3o – hPTP SHP-1 catalytic domain
1x6c - hPTP SHP-1 SH2 domain – NMR
2shp - hPTP SHP-2 (mutant)
2b49 – hPTPN3 catalytic domain
2i75 – hPTPN4
2cs5 – hPTPN4 PDZ domain – NMR
2vph - hPTPN4 PDZ domain
2bij – hPTPN5 catalytic domain
2bv5 - hPTPN5 catalytic domain (mutant)
3ps5 – hPTPN6 (mutant)
4hjp – hPTPN6 catalytic domain
4gry, 4grz, 4hjq – hPTPN6 catalytic domain (mutant)
2dn7 - hPTPN6 FN3 #6 domain - NMR
2dju, 2edy - hPTPN6 FN3 domain - NMR
2a3k, 1zc0 – hPTPN7 catalytic domain
2gp0, 2hvl, 2qdc, 2qdm, 2qdp, 2qds, 2qdt, 2qdu, 3o4s, 3o4t, 3o4u – hPTPN7 catalytic domain (mutant)
2pa5 – hPTPN9 catalytic domain
3b7o, 3zm0, 3zm1, 3zm2, 3zm3 - hPTPN11 catalytic domain
4dgp - hPTPN11 SH2+catalytic domains
4dgx, 4gwf, 4h1o, 4h34 - hPTPN11 SH2+catalytic domains (mutant)
3lnx – hPTPN13 PDZ2 domain
2m0z - hPTPN13 PDZ2 domain (mutant) – NMR
2bzl – hPTPN14 catalytic domain
2oc3 – hPTPN18
2p6x, 2qcj, 3h2x – hPTPN22 catalytic domain
3rau - hPTPN23 His domain
1xm2 – hPTP PRL-1
1r6h, 1v3a, 2mbc – hPTP IVA-3 – NMR
1rxd - hPTP IVA-1
1zck, 1x24 – rPTP 4A1 – rat
3i36 – rPTP-η catalytic domain
1c0e – bPTP (mutant) – bovine
1d1p, 2j16 – yPTP - yeast
2j17 - yPTP (mutant)
1g4w – StPTP – Salmonella typhimurium
2i6i, 3ro1 – SsPTP – Sulfolobus solfataricus
2pi7 – cPTP CRYP-2 catalytic domain
2z72, 1v73, 2zbm – PTP residues 22-361 – Shewanella
3js5, 3jvi – EhPTP – Entamoeba histolytica
2wjd, 2wje, 2wjf – PTP – Streptococcus pneumonia
3qy6, 3qy7, 3qy8 – BsPTP – Bacillus subtilis
Non-receptor type PTP complex with peptide
1ptt, 1ptu, 1g1f, 1g1g, 1g1h, 1een, 1eeo - hPTP-b catalytic domain (mutant) + peptide
3i7z - hPTP-b catalytic domain + peptide
3zmp, 3zmq – hPTPN1 catalytic domain + peptide
1bzh - hPTP 1B catalytic domain + fluoromalonyl tyrosine peptide
1bzj - hPTP 1B catalytic domain + phosphotyrosine mimetic
3nfk, 3nfl - hPTPN4 PDZ domain + peptide
2yu7, 2rmx – hPTPN6 SH2 domain + peptide – NMR
4gs0 – hPTPN6 catalytic domain + peptide
3d42, 3d44 – hPTPN7 catalytic domain (mutant) + peptide
4icz – hPTPN9 catalytic domain + peptide
3tl0, 3tkz – hPTPN11 SH2 domain + peptide
3lny - hPTPN13 PDZ2 domain + peptide
4gfu, 4gfv - hPTPN18 residues 6-300 + peptide
3brh, 3olr - hPTPN22 catalytic domain + peptide
3omh - hPTPN22 catalytic domain (mutant) + peptide
3rz2 - rPTP 4A1 + peptide
1fpr - hPTP SHP-1 catalytic domain + peptide
1aya, 1ayb, 1ayc, 1ayd – mPTP Syp N terminal SH2 domain + peptide
1vj6 – mPTP PDZ2 domain + APC C terminal – NMR
2dxp, 2i6o – SsPTP (mutant) + peptide
Non-receptor type PTP complex with small molecule
1ptv, 1pty - hPTP-b catalytic domain (mutant) + phosphotyrosine
1aax - hPTP-b catalytic domain (mutant) + bis-phosphophenyl methane
1ecv, 1c83, 1c84, 1c85, 1c86, 1c87, 1c88, 1g7f, 1g7g, 1jf7, 1l8g, 1kak, 1kav, 1lqf, 1nl9, 1nny, 1no6, 1nz7, 1ony, 1onz, 1ph0, 1pxh, 1pyn, 1q1m, 1q6j, 1q6m, 1q6n, 1q6p, 1q6s, 1q6t, 1qxk, 1t48, 1t49, 1t4j, 1xbo, 1wax, 2bgd, 2bge, 2azr, 2b07, 2f6t, 2f6v, 2f6w, 2f6y, 2f6z, 2f70, 2f71, 2fjn, 2cm7, 2cm8, 2cma, 2cmb, 2cmc, 2h4g, 2h4k, 2hb1, 2cne, 2cnf, 2cng, 2cnh, 2cni, 2nt7, 2nta, 2veu, 2vev, 2vew, 2vex, 2vey, 2qbp, 2qbq, 2qbr, 2qbs, 3cwe, 3d9c, 2zmm, 2zn7, 3eax, 3eb1, 3sme, 4i8n - hPTP-b catalytic domain + inhibitor
1nwl, 1nwe, 2fjm - hPTP-b catalytic domain (mutant) + inhibitor
4bjo – hPTP1 catalytic domain + NO3
3rgq – mPTP-1 + Pi(5)P
2cjz - hPTPN5 catalytic domain (mutant) + phosphotyrosine
4ge2, 4ge5, 4ge6 – hPTP9 catalytic domain + inhibitor
3o5x – hPTPN11 catalytic domain + inhibitor
3mow - hPTPN11 catalytic domain + tautomycetin analog
2m10 - hPTPN13 PDZ2 domain (mutant) + azobenzene derivative – NMR
2qct, 4j51 – hPTPN22 catalytic domain + inhibitor
1zcl - rPTP 4A1 (mutant) + sulfate
1dg9 – bPTP + HEPES
1d2a – yPTP + adenine
1d1q – yPTP (mutant) + PNPP
2i6p - SsPTP (mutant) + PNPP
2i6j – SsPTP + phosphate
2i6m – SsPTP + WO4
3ido – EhPTP + HEPES
Non-receptor type PTP complex with protein
2b4s - hPTP-b catalytic domain + insulin receptor
2gph - hPTPN7 catalytic domain (mutant) + MAPK2
1g4u – StPTP + RAS-related C3 botulinum toxin substrate
1jyo – StPTP + secretion chaperone SICP
4je4, 4jeg – hPTPN11 catalytic domain + monobody
Yersinia PTP Yop
1yts, 2i42, 3f99 - YePTP catalytic domain (mutant) – Yersinia enterocolitica
1xxp, 1xxv - YePTP catalytic domain (mutant) + peptide
2i42 – YePTP (mutant) + VO4
1ypt, 1ytw – YePTP catalytic domain + WO4
1ytn - YePTP catalytic domain + NO3
1lyv - YePTP catalytic domain (mutant) + phosphate
3f9a – YeYop catalytic domain (mutant) + tungstate
3f9b – YeYop catalytic domain (mutant) + divanadate
1pa9, 3bm8 - YePTP catalytic domain (mutant) + inhibitor
3blu, 3blt - YeYopH catalytic domain + inhibitor
3u96 - YeYopH catalytic domain (mutant) + inhibitor
4gf3 – YeYop residues 21-63 + YeYop targeting protein SYNCH
1huf – YpYopH N terminal – Yersinia pestis
1qz0 - YpYopH catalytic domain (mutant) + peptide
2y2f - YpYopH catalytic domain + inhibitor
1k46 - YptYopH N terminal – Yersinia pseudotuberculosis
1m0v - YptYopH N terminal + phosphopeptide - NMR
Receptor-type PTP
1yfo, 2i1y – mRPTP-α catalytic domain
1p15 - mRPTP-α D2 domain
3pxh - mRPTP Ig domains
2nv5 – RPRP - rat
2ahs – hRPTP-β
2i3r, 2i5x - hRPTP-β catalytic domain
2hc1, 2hc2 - hRPTP-β catalytic domain (mutant)
2h4v, 2pbn – hRPTP-γ domain 1
3qcn - hRPTP-γ domain 1 (mutant)
2nlk - hRPTP-γ catalytic domain
3jxg, 3jxh - mRPTP-γ CA-like domain
3jxh - hRPTP-γ CA-like domain
1x5z - hRPTP-δ fibronectin type-III domain – NMR
2dlh - hRPTP-δ FN3 domain – NMR
2yd6, 2yd7 - hRPTP-δ Ig1-2 domain
2jjd - hRPTP-ε residues 107-697
2c7s - hRPTP-κ residues 865-1154
1rpm - hRPTP-μ catalytic domain
2c9a - hRPTP-μ MAM-IG module
2v5y - hRPTP-μ extracellular region
2g59, 2gjt - hRPTP-ο catalytic domain
2cfv – hRPTP-η residues 1019-1311
2nz6 - hRPTP-η residues 1019-1311 (mutant)
2dle - hRPTP-η FN3 domain – NMR
2qep – hRPTP-ν2 D1 domain
4hti, 4htj – hRPTP-ν2 membrane proximal ectodomain
2ooq – hRPTP-ρ
2fh7, 4bpc - hRPTP-σ catalytic domain (mutant)
2yd9 - hRPTP-σ Ig1-3 domain (mutant)
2yd3, 2yd5 - hRPTP-σ Ig1-2 domain
2yd4 - cRPTP-σ Ig1-2 domain – chicken
3jxf - hRPTP-ζ CA-like domain
2qt7, 3n01, 3n4w, 3ng8, 3np5 – hRPTP IA-2
1jln, 2a8b - mRPTP-R catalytic domain
3sr9 - mRPTP-σ residues 1326 – 1901
2edx - hRPTP-F fibronectin type-III domain – NMR
2yd1, 2yd2, 3pxj – DmRPTP Ig1-2 domain – Drosophila melanogaster
3s3e – DmRPTP-10D catalytic domain
Receptor type PTP complexes
3s3f - DmRPTP-10D catalytic domain + VO4
3s3h - DmRPTP-10D catalytic domain + peptide
3s3k - DmRPTP-10D catalytic domain + inhibitor
2h02, 2h04, 2i3u, 2i4e, 2i4g, 2i4h - hRPTP-β catalytic domain + inhibitor
2h03 - hRPTP-β catalytic domain (mutant) + inhibitor
2hy3, 3qcb, 3qcc, 3qcd - hRPTP-γ domain 1 + VO4
3qce, 3qcf, 3qcg, 3qch, 3qci, 3qcj, 3qck - hRPTP-γ domain 1 + inhibitor
3qcl, 3qcm - hRPTP-γ domain 1 (mutant) + inhibitor
3kld - mRPTP-γ CA-like domain + contactin 4
2yd8 - hRPTP-σ Ig1-2 domain + sucrose octasulfate
3s97 - hRPTP-ζ CA-like domain + congtactin Ig domains
1ygr – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide
Dual-specificity PTP
1t3k – DUSP (mutant) – Arabidopsis thaliana
2g6z – DUSP-5
3lj8 – DUSP-9
2wgp – hDUSP-14 residues 2-191
Class II – Low molecular weight PTP
1p8a – PTP (mutant) – Tritrichomonas foetus – NMR
2cwd – PTP – Thermus thermophilus
1phr - bPTP
1xww - hPTP
1z12 - bPTP + VO4
1z13 - bPTP + MoO4
3rof – PTP-A + peptide – Staphylococcus aureus
1u2p, 2luo – MtPTP – Mycobacterium tuberculosis
1u2q – MtPTP + glycerol
2oz5 – MtPTP + inhibitor
2fek – PTP – Escherichia coli
4eti, 4etm, 4kk3 – BsPTP
4etn, 4kk4 – BsPTP (mutant)
Class III – CDC25
1c25 – hCDC25A catalytic domain (mutant)
1qb0, 1cwr, 1ym9, 1ymd, 1ymk, 1yml, 1ys0, 2uzq - hCDC25B catalytic domain
2a2k, 2ifd, 2ifv - hCDC25B catalytic domain (mutant)
1cwr, 1cws - hCDC25B catalytic domain + WO4
1cwt - hCDC25B catalytic domain + Methyl-Hg
3op3 – hCDC25C residues 270-462
T-cell PTP
1l8k – hTC-PTP
4az1 – PTP – Trypanosoma cruzi
