Function
Squalene-hopene cyclase (SHC) catalyzes the conversion of acyclic squalene into the pentacyclic hopene and hopanol in prokaryotes. The reaction which SHC cactalyzes involves the breaking or forming of 13 covalent bonds, the formation of 9 chiral centers and the formation of 5 rings in a single step.
Disease
Relevance
The hopenoids condense lipid membranes and reduce their permeability.
Structural highlights
3D structures of squalene-hopene cyclase
Updated on 24-September-2014
SHC
1sqc – AaSHC – Alicyclobacillus acidocaldarius
2sqc, 3sqc – AaSHC (mutant)
SHC complexes
1gsz – AaSHC + drug
1h35, 1h36, 1h37, 1h39, 1h3a, 1h3b, 1h3c, 1o6h, 1o6q, 1o6r, 1o79 – AaSHC + inhibitor
1ump – AaSHC + 2-azasqualene
References
