Tyrosine phosphatase

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Tyrosine phosphatase (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways. PTPs are divided to 4 subfamilies. PTP class I contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. PTP class III contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP. For details on Yersinia PTP see Yersinia YopH.

3D Structures of tyrosine phosphatase

Updated on 16-December-2014

Class I

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Michal Harel, Joel L. Sussman

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