Aldose Reductase

Function

Aldose Reductase (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway.

Disease

The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR.

Structural highlights

AldR structure is of a β/α-barrel. The active site is located in the barrel core.