Function
Chloramphenicol acetyltransferase (CAT) is an enzyme which makes bacteria resistant to chloramphenicol. It attaches acetyl from acetyl-CoA to chloramphenicol thus preventing it from binding to the ribosome. Additional details in Chloramphenicol Acetyltransferase Type III.[1]
Structural highlights
. In CAT III chloramphenicol binds in a deep pocket at the interface of 2 subunits.