User:Kurt Corsbie/Sandbox 1

From Proteopedia

Metabotropic Glutamate Receptor 5 mGlu5 Homo sapiens

Class C GPCR

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Structure 2.1 Domain highlights 3 Disease 4 Relevance 5 Structural highlights Function G protein-coupled receptors (GPCRs) can be broken up into four classes: A, B, C, and F. [1]. Metabotropic glutamate receptor 5 (mGLu5) is a Class C GPCR that couples with the Gq pathway [2]. Structure Hydrophobic Pocket Surrounding Mavoglurant Image:Mav HB 1.1.png Hydrogen Bonding interactions between protein and Mavoglurant Further Hydrogen Bonding between protein and Mavoglurant Domain highlights Disease Relevance Structural highlights

References

1. ↑ Venkatakrishnan AJ, Deupi X, Lebon G, Tate CG, Schertler GF, Babu MM. Molecular signatures of G-protein-coupled receptors. Nature. 2013 Feb 14;494(7436):185-94. doi: 10.1038/nature11896. PMID:23407534 doi:http://dx.doi.org/10.1038/nature11896
2. ↑ Pin JP, Galvez T, Prezeau L. Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors. Pharmacol Ther. 2003 Jun;98(3):325-54. PMID:12782243