Poly (ADP-ribose) polymerase

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Function

Poly (ADP-ribose) polymerase (PARP) is involved in DNA repair and programmed cell death. The PARP family contains 17 members. PARP is composed of 4 domains. Among them are the N terminal DNA-binding domain which contains 2 zinc fingers; auto modification domain which contains a WGR-rich domain; C terminal which includes the catalytic domain (or PARP domain).

PARP-1 and PARP-2 recognize and is activated by DNA breaks^[1], ^[2].
PARP-3 prevents from extensive end resection to promote double-strand DNA repair ^[3].
PARP-10 contains a RNA recognition motif (RRM).
Tankyrase (Tank) is a PARP which contains ankyrin repeats (a 33-residue repeat with 2 α-helices separated by loops).