Thioredoxin Reductase

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Contents 1 Function 2 Disease 3 3D Structures of Thioredoxin Reductase 4 References

Function

Thioredoxin Reductase (TrxR) is an enzyme which reduces thioredoxin using NADPH^[1]. TrxR-2 is mitochondrial. For more details see User:Sarah Abdalla/Thioredoxin Reductase.

Disease

Mutations in TrxR-2 are associated with familial glucocorticoid deficiency^[2].

3D Structures of Thioredoxin Reductase

Updated on 13-September-2016

References

1. ↑ Arner ES, Holmgren A. Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem. 2000 Oct;267(20):6102-9. PMID:11012661
2. ↑ Prasad R, Chan LF, Hughes CR, Kaski JP, Kowalczyk JC, Savage MO, Peters CJ, Nathwani N, Clark AJ, Storr HL, Metherell LA. Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). J Clin Endocrinol Metab. 2014 Aug;99(8):E1556-63. doi: 10.1210/jc.2013-3844. Epub, 2014 Mar 6. PMID:24601690 doi:http://dx.doi.org/10.1210/jc.2013-3844