Transthyretin

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Contents 1 Function 2 Disease 3 3D structures of transthyretin 4 References

Function

Transthyretin (TTR) is a serum carrier of the thyroid hormone thyroxine (T4) and retinol through its association with retinol-binding protein (RBP). Many small molecules bind to TTR T4-binding site^[1]. For details see Student Project 2 for UMass Chemistry 423 Spring 2015.

Disease

TTR mutations are associated with amyloid deposition^[2].

3D structures of transthyretin

Updated on 21-September-2016

References

1. ↑ Robbins J. Transthyretin from discovery to now. Clin Chem Lab Med. 2002 Dec;40(12):1183-90. PMID:12553418 doi:http://dx.doi.org/10.1515/CCLM.2002.208
2. ↑ Saraiva MJ. Transthyretin mutations in health and disease. Hum Mutat. 1995;5(3):191-6. PMID:7599630 doi:http://dx.doi.org/10.1002/humu.1380050302