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Kappa opioid receptor (KOR) belongs to the opioid system. This system plays an essential role in addiction. Opioid receptors and endogenous opioid peptides are very widely present in brain structures that control reward phenomena, particularly the mesolimbic system. These opioid receptors and peptides participate selectively in several aspects of the addictive processes induced by opiates, cannabinoids, psychostimulants, alcohol and nicotine.
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Structural highlights
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