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General Description
Human polymerase θ (pol θ) is large, 290kD enzyme consisting of three distinct domains (1,2). An N-terminal helicase-like domain, whose exact cellular functions are a topic of on-going debate and research (3,4), is linked to a C-terminal, family A DNA polymerase domain by a large and disordered central region (2). Notably, pol θ is the only known human polymerase to contain a polymerase and helicase domain in one molecule (5). The focus of this page is the polymerase domain.
Pol θ is thought to promote overall genomic stability by performing several distinct cellular functions. The primary role of the enzyme is to repair of double-stranded DNA breaks as the key enzyme in an error-prone non-homologous end-joining pathway called alternative end-joining (6) or theta-mediated end-joining.
Structural Highlights
Structural Insights into Function
Related Proteins
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