Function
Dihydroorotase (DHO) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate in the pyrimidine biosynthesis pathway[1].
Relevance
The difference between bacterial and mammalian DHO makes it a promising drug target[2].
Structural highlights
The 3D structure of the complex of DHO with dihydroorotate and carbamoyl aspartate shows these contacts includes electrostatic interactions. The substrate carbamoyl aspartate binds to the active site of subunit B via 2 Thr residues[3].
3D structures of dihydroorotase
Dihydroorotase 3D structures
