User:Tilman Schirmer/Sandbox 201

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Diguanylate cyclases

Contents 1 1. PleD 1.1 1.1 Intro 1.2 1.2 Domain structure 1.3 1.3 Protomer 1.4 1.4 Substrate binding site 1.5 1.5 Allosteric product binding site 1.5.1 C-di-GMP 1.5.2 Primary inhibition site (Ip) 1.5.3 Secondary inhibition site (Is) 1.5.4 Primary and secondary inhibition sites 1.6 1.6 Two conformations 1.7 1.7 Non-activated conformation 1.8 1.8 Activated conformation 2 2. WspR

1. PleD

1.1 Intro

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1.2 Domain structure

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1.3 Protomer

spinqualitylabelsall models 2v0n Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

: , ,

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1.4 Substrate binding site

spinqualitylabelsall models 2v0n Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

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1.5 Allosteric product binding site

spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

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C-di-GMP

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Primary inhibition site (Ip)

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Secondary inhibition site (Is)

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Primary and secondary inhibition sites

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1.6 Two conformations

spinqualitylabelsall models non-activated (1w25) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

spinqualitylabelsall models activated (BeF3- modified; 2v0n) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

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1.7 Non-activated conformation

1w25

spinqualitylabelsall models 1w25 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

: , ,

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1.8 Activated conformation

2v0n

spinqualitylabelsall models 2v0n Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

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2. WspR