User:Tilman Schirmer/Sandbox 203

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C-di-GMP receptors with PilZ domain

PlzD

spinqualitylabelsall models PlzD 1yln Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

from Vibrio cholerae is composed of a and a C-terminal domain (with very similar fold).

The c-di-GMP is formed by arginine residues of the inter-domain linker and the PlzD domain surface .

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PlzD in complex with c-di-GMP

spinqualitylabelsall models PlzD 2rde Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Upon complex formation the relative domain arrangement is (compare with 1yln above), .

References

PlzD structure 1yln:

• Ramelot TA, Yee A, Cort JR, Semesi A, Arrowsmith CH, Kennedy MA. NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein. Proteins. 2007 Feb 1;66(2):266-71. PMID:17096419 doi:10.1002/prot.21199

PlzD - c-di-GMP structure 2rde:

• Benach J, Swaminathan SS, Tamayo R, Handelman SK, Folta-Stogniew E, Ramos JE, Forouhar F, Neely H, Seetharaman J, Camilli A, Hunt JF. The structural basis of cyclic diguanylate signal transduction by PilZ domains. EMBO J. 2007 Dec 12;26(24):5153-66. Epub 2007 Nov 22. PMID:18034161