2mdl

Structural highlights

Function

ALPS_SCYSE Binds to bacterial LPS and may specifically inhibit the LPS-mediated activation of the hemolymph coagulation. It has a strong antibacterial effect especially on the growth of Gram-negative bacteria.^{[1] [2]}

References

1. ↑ Yedery RD, Reddy KV. Identification, cloning, characterization and recombinant expression of an anti-lipopolysaccharide factor from the hemocytes of Indian mud crab, Scylla serrata. Fish Shellfish Immunol. 2009 Aug;27(2):275-84. doi: 10.1016/j.fsi.2009.05.009., Epub 2009 May 31. PMID:19490944 doi:10.1016/j.fsi.2009.05.009
2. ↑ Sharma S, Yedery RD, Patgaonkar MS, Selvaakumar C, Reddy KV. Antibacterial activity of a synthetic peptide that mimics the LPS binding domain of Indian mud crab, Scylla serrata anti-lipopolysaccharide factor (SsALF) also involved in the modulation of vaginal immune functions through NF-kB signaling. Microb Pathog. 2011 Mar-Apr;50(3-4):179-91. doi: 10.1016/j.micpath.2010.12.007., Epub 2010 Dec 30. PMID:21195157 doi:10.1016/j.micpath.2010.12.007