Structural highlights
Function
C5DN49_LACTC
Publication Abstract from PubMed
14-3-3 proteins bind phosphorylated binding partners to regulate several of their properties, including enzymatic activity, stability and subcellular localization. Here, two crystal structures are presented: the crystal structures of the 14-3-3 protein (also known as Bmh1) from the yeast Lachancea thermotolerans in the unliganded form and bound to a phosphopeptide derived from human PI4KB (phosphatidylinositol 4-kinase B). The structures demonstrate the high evolutionary conservation of ligand recognition by 14-3-3 proteins. The structural analysis suggests that ligand recognition by 14-3-3 proteins evolved very early in the evolution of eukaryotes and remained conserved, underlying the importance of 14-3-3 proteins in physiology.
Crystal structures of a yeast 14-3-3 protein from Lachancea thermotolerans in the unliganded form and bound to a human lipid kinase PI4KB-derived peptide reveal high evolutionary conservation.,Eisenreichova A, Klima M, Boura E Acta Crystallogr F Struct Biol Commun. 2016 Nov 1;72(Pt 11):799-803. Epub 2016, Oct 24. PMID:27827352[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Eisenreichova A, Klima M, Boura E. Crystal structures of a yeast 14-3-3 protein from Lachancea thermotolerans in the unliganded form and bound to a human lipid kinase PI4KB-derived peptide reveal high evolutionary conservation. Acta Crystallogr F Struct Biol Commun. 2016 Nov 1;72(Pt 11):799-803. Epub 2016, Oct 24. PMID:27827352 doi:http://dx.doi.org/10.1107/S2053230X16015053