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Calcium/calmodulin-dependent protein kinase kinase

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Human CaMKKβ complex with the thiadiazinone inhibitor and Mg+2 ion (green) (PDB code 5vt1)

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3D structures of calcium/calmodulin-dependent protein kinase kinase

Updated on 28-June-2020

6ccf, 6cd6 - hCaMKKαA + inhibitor - human
5uy6, 5uyj - hCaMKKβB
5vt1, 6bku, 6ble, 6bql, 6bqq, 6brc, 6cmj, 2zv2 - hCaMKKβB + inhibitor
5yv8, 5yv9, 5yva, 5yvb, 5yvc - hCaMKKβ + inhibitor
6bqp - hCaMKKβB + drug
6fel - hCaMKKβ + 14-3-3 protein g
1ckk - CaMKK1 calmodulin-binding domain + calmodulin - rat - NMR

References

  1. ↑ Shen QW, Zhu MJ, Tong J, Ren J, Du M. Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes. Am J Physiol Cell Physiol. 2007 Oct;293(4):C1395-403. doi:, 10.1152/ajpcell.00115.2007. Epub 2007 Aug 8. PMID:17687000 doi:http://dx.doi.org/10.1152/ajpcell.00115.2007
  2. ↑ Matsushita M, Nairn AC. Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase. J Biol Chem. 1999 Apr 9;274(15):10086-93. PMID:10187789
  3. ↑ Takemoto-Kimura S, Suzuki K, Horigane SI, Kamijo S, Inoue M, Sakamoto M, Fujii H, Bito H. Calmodulin kinases: essential regulators in health and disease. J Neurochem. 2017 Jun;141(6):808-818. doi: 10.1111/jnc.14020. Epub 2017 Apr 17. PMID:28295333 doi:http://dx.doi.org/10.1111/jnc.14020
  4. ↑ Takemoto-Kimura S, Suzuki K, Horigane SI, Kamijo S, Inoue M, Sakamoto M, Fujii H, Bito H. Calmodulin kinases: essential regulators in health and disease. J Neurochem. 2017 Jun;141(6):808-818. doi: 10.1111/jnc.14020. Epub 2017 Apr 17. PMID:28295333 doi:http://dx.doi.org/10.1111/jnc.14020
  5. ↑ Liu L, Yuan H, Denton K, Li XJ, McCullough L, Li J. Calcium/calmodulin-dependent protein kinase kinase beta is neuroprotective in stroke in aged mice. Eur J Neurosci. 2016 Aug;44(4):2139-46. doi: 10.1111/ejn.13299. PMID:27305894 doi:http://dx.doi.org/10.1111/ejn.13299
  6. ↑ Asquith CRM, Godoi PH, Counago RM, Laitinen T, Scott JW, Langendorf CG, Oakhill JS, Drewry DH, Zuercher WJ, Koutentis PA, Willson TM, Kalogirou AS. 1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors. Molecules. 2018 May 19;23(5). pii: molecules23051221. doi:, 10.3390/molecules23051221. PMID:29783765 doi:http://dx.doi.org/10.3390/molecules23051221

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