Hypoxia-Inducible factor 1 alpha inhibitor

From Proteopedia

3D Structures of Hypoxia-Inducible factor 1 alpha inhibitor

Updated on 17-September-2025 {{#tree:id=OrganizedByTopic|openlevels=0|

• Hypoxia-inducible factor 1 alpha inhibitor

• • 1iz3, 1mze, 2cgn, 2cgo – hFIH-1 – human
    
  • 3kcx, 3kcy, 4bio, [[9iif] – hFIH-1 + quinoline inhibitor
    
  • 2wa3, 2wa4, 3od4, 4ai8, 5op6, 5op8, 5opc, 8ihz, 8ii0, 9i4h, 9jtx – hFIH-1 + inhibitor
    
  • 9fsn – hFIH-1 + drug
    
  • 1yci – hFIH-1 + Phe derivative
    
  • 1h2n, 1mzf, 2w0x, 2yc0, 2yde, 4z2w, 7a1j, 7a1k, 7a1l, 7a1m – hFIH-1 + glutarate derivative
    
  • 5jwk, 5jwl – hFIH-1 (mutant) + glutarate derivative
    
  • 4z1v – hFIH-1 + oxalylglycine
    

• Hypoxia-inducible factor 1 alpha inhibitor complex with peptide

• • 2xum – hFIH-1 (mutant) + peptide
    
  • 1h2l – hFIH-1 + HIF-1 peptide + glutarate derivative
    
  • 2ilm, 3d8c, 5jwp – hFIH-1 (mutant) + HIF-1 peptide + glutarate derivative
    
  • 2y0i, 7a1s – hFIH-13 + tankyrase-2 peptide + glutarate derivative
    
  • 3p3n, 3p3p – hFIH-1 + notch 1 peptide + glutarate derivative
    
  • 4z1v – hFIH-1 + oxalylglycine
    
  • 1h2k, 1h2m – hFIH-1 + HIF-1 peptide + oxalylglycine
    
  • 6h9j, 6ha6 – hFIH-1 + TRPV3 peptide + oxalylglycine
    
  • 6hc8 – hFIH-1 + TRPA1 peptide + oxalylglycine
    
  • 6hl5, 6hl6 – hFIH-1 + ASPP1 peptide + oxalylglycine
    
  • 6hkp – hFIH-1 + ASPP2 peptide + oxalylglycine
    
  • 4b7e, 4b7k, 4jaa, 4rn1, 6ruj – hFIH-1 + concensus Ankyrin-repeat domain peptide + oxalylglycine
    
  • 7a1n, 7a1o, 7a1p, 7a1q – hFIH-1 + concensus Ankyrin-repeat domain peptide + oxoglutaraste derivative
    

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References

1. ↑ Mahon PC, Hirota K, Semenza GL. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 2001 Oct 15;15(20):2675-86. PMID:11641274 doi:http://dx.doi.org/10.1101/gad.924501
2. ↑ Kiriakidis S, Henze AT, Kruszynska-Ziaja I, Skobridis K, Theodorou V, Paleolog EM, Mazzone M. Factor-inhibiting HIF-1 (FIH-1) is required for human vascular endothelial cell survival. FASEB J. 2015 Jul;29(7):2814-27. doi: 10.1096/fj.14-252379. Epub 2015 Apr 2. PMID:25837583 doi:http://dx.doi.org/10.1096/fj.14-252379
3. ↑ Chen T, Ren Z, Ye LC, Zhou PH, Xu JM, Shi Q, Yao LQ, Zhong YS. Factor inhibiting HIF1alpha (FIH-1) functions as a tumor suppressor in human colorectal cancer by repressing HIF1alpha pathway. Cancer Biol Ther. 2015;16(2):244-52. doi: 10.1080/15384047.2014.1002346. PMID:25602156 doi:http://dx.doi.org/10.1080/15384047.2014.1002346
4. ↑ Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ. Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha. J Biol Chem. 2003 Jan 17;278(3):1802-6. Epub 2002 Nov 21. PMID:12446723 doi:http://dx.doi.org/10.1074/jbc.C200644200