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Tyrosine phosphatase

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Human tyrosine phosphatase 1B catalytic domain (grey) complex with EGFR peptide (in green), VO4, glycerol, Tris, 2-amino-2-hydroxymethyl-1,3-diol, 3i7z

Drag the structure with the mouse to rotate

1 Function
2 Disease
3 3D Structures of tyrosine phosphatase
4 References

Function

Tyrosine phosphatase or Protein tyrosine phosphatase (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways^[1]. PTPs are divided to 4 subfamilies.

PTP class I contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. Human PTP PRL is found in regenerating liver.
PTP class II are low molecular weight PTP (LMW-PTP) which dephosphorylate a number of growth factors and modulate their signalling processes^[2].
PTP class III contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP.
Yersinia PTP see Yersinia YopH.
Non-receptor type PTPs are coded by the PTPN genes.
T-cell PTP is a non-receptor type PTP expressed in hematopoietic tissues influencing most cells in the immune system^[3].

For details of PTP complex with inhibitor see Student Projects for UMass Chemistry 423 Spring 2012-9.

Disease

PTP mutations are involved in cancers^[4].

3D Structures of tyrosine phosphatase

Tyrosine phosphatase 3D structures

References

↑ Paul S, Lombroso PJ. Receptor and nonreceptor protein tyrosine phosphatases in the nervous system. Cell Mol Life Sci. 2003 Nov;60(11):2465-82. PMID:14625689 doi:http://dx.doi.org/10.1007/s00018-003-3123-7
↑ Caselli A, Paoli P, Santi A, Mugnaioni C, Toti A, Camici G, Cirri P. Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme. Biochim Biophys Acta. 2016 Oct;1864(10):1339-55. doi:, 10.1016/j.bbapap.2016.07.001. Epub 2016 Jul 13. PMID:27421795 doi:http://dx.doi.org/10.1016/j.bbapap.2016.07.001
↑ Doody KM, Bourdeau A, Tremblay ML. T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease. Immunol Rev. 2009 Mar;228(1):325-41. PMID:19290937 doi:10.1111/j.1600-065X.2008.00743.x
↑ Ostman A, Hellberg C, Bohmer FD. Protein-tyrosine phosphatases and cancer. Nat Rev Cancer. 2006 Apr;6(4):307-20. PMID:16557282 doi:http://dx.doi.org/10.1038/nrc1837