Epidermal growth factor

Function

Epidermal growth factor (EGF) plays a role in cell growth. It binds to its receptor (EGFR). EGF is regulated by iodine. EGF is part of a family of proteins with similar structure and activity.^[1] Some details
on EGF exon in EGF1
on Gla domain in Gla domain
Pre-prozymogen.

Relevance

EGFR-dependent cancers are deprived of stimulus by EGF by raising antibodies against EGF via vaccination.

Structural highlights

All EGF family proteins contain a conserved amino acid sequence which includes (PDB code 1jl9).^[2]